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Modulation of pain in pediatric sickle cell disease: understanding the balance between endothelin mediated vasoconstriction and apelin mediated vasodilation
Children with sickle cell disease (SCD) have painful vaso-occlusive episodes (VOE), which often reoccur across the individual's lifespan. Vaso-constrictive and vaso-dilatory molecules have been hypothesized to play a role in VOEs. Endothelin-1 (ET-1) is a potent vasoconstrictor that is released...
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| Publicado no: | Blood Cells Mol Dis |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4297528/ https://ncbi.nlm.nih.gov/pubmed/25486928 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcmd.2014.11.016 |
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