New Plasmid-Mediated Nucleotidylation of Aminoglycoside Antibiotics in Staphylococcus aureus

A wild-type strain of Staphylococcus aureus, which inactivates a wide variety of aminoglycosides (except the gentamicin components), has been found to harbor a plasmid (RAp01) that mediates the biosynthesis of a nucleotidyltransferase. This enzyme modifies the 4′-hydroxy function of these antibiotic...

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Bibliographic Details
Main Authors: Goffic, F. Le, Martel, A., Capmau, M. L., Baca, B., Goebel, P., Chardon, H., Soussy, C. J., Duval, J., Bouanchaud, D. H.
Format: Artigo
Language:Inglês
Published: 1976
Subjects:
Biosynthesis; Chemistry; Mechanisms of Action and Resistance
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC429732/
https://ncbi.nlm.nih.gov/pubmed/984767
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