New Plasmid-Mediated Nucleotidylation of Aminoglycoside Antibiotics in Staphylococcus aureus

A wild-type strain of Staphylococcus aureus, which inactivates a wide variety of aminoglycosides (except the gentamicin components), has been found to harbor a plasmid (RAp01) that mediates the biosynthesis of a nucleotidyltransferase. This enzyme modifies the 4′-hydroxy function of these antibiotic...

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Publicat a:Antimicrob Agents Chemother
Autors principals: Goffic, F. Le, Martel, A., Capmau, M. L., Baca, B., Goebel, P., Chardon, H., Soussy, C. J., Duval, J., Bouanchaud, D. H.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology (ASM) 1976
Matèries:
Biosynthesis; Chemistry; Mechanisms of Action and Resistance
Accés en línia:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC429732/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/984767/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.10.2.258
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