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A New Cephalosporin with a Dual Mode of Action

A cephalosporin, (6R,7R)-7-[(2R)-2-hydroxy-2-phenylacetamido]-3-(pyrid-2-yl-N-oxide) thiomethylceph-3-em-4-carboxylic acid (MCO), that could lead to a novel approach to the problem of β-lactamase destruction is described. The compound is slightly more resistant to some β-lactamases than is cephaloth...

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Bibliographic Details
Published in:Antimicrob Agents Chemother
Main Authors: O'Callaghan, Cynthia H., Sykes, R. B., Staniforth, Susan E.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 1976
Subjects:
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC429729/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/984765/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.10.2.245
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