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A Critical Role for CRM1 in Regulating HOXA Gene Transcription in CALM-AF10 Leukemias
The leukemogenic CALM-AF10 fusion protein is found in patients with immature acute myeloid and T-lymphoid malignancies. CALM-AF10 leukemias display abnormal H3K79 methylation and increased HOXA cluster gene transcription. Elevated expression of HOXA genes is critical for leukemia maintenance and pro...
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| Udgivet i: | Leukemia |
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| Main Authors: | , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2014
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4297268/ https://ncbi.nlm.nih.gov/pubmed/25027513 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2014.221 |
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