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Parallel Synthesis of Cell-Penetrating Peptide Conjugates of PMO Toward Exon Skipping Enhancement in Duchenne Muscular Dystrophy

We describe two new methods of parallel chemical synthesis of libraries of peptide conjugates of phosphorodiamidate morpholino oligonucleotide (PMO) cargoes on a scale suitable for cell screening prior to in vivo analysis for therapeutic development. The methods represent an extension of the SELecti...

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Detalhes bibliográficos
Publicado no:Nucleic Acid Ther
Main Authors: O'Donovan, Liz, Okamoto, Itaru, Arzumanov, Andrey A., Williams, Donna L., Deuss, Peter, Gait, Michael J.
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4296749/
https://ncbi.nlm.nih.gov/pubmed/25412073
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/nat.2014.0512
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