Deficiency of Patched 1-induced Gli1 signal transduction results in astrogenesis in Swedish mutated APP transgenic mice

Normally, sonic hedgehog (Shh) signaling induces high levels of Patched 1 (Ptc1) and its associated transcription factor Gli1 with genesis of specific neuronal progeny. But their roles in the neural stem cells (NSCs), including glial precursor cells (GPCs), of Alzheimer's disease (AD) are uncle...

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Vydáno v:Hum Mol Genet
Hlavní autoři: He, Ping, Staufenbiel, Matthias, Li, Rena, Shen, Yong
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2014
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4296204/
https://ncbi.nlm.nih.gov/pubmed/25027328
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddu370
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