The R292K Mutation That Confers Resistance to Neuraminidase Inhibitors Leads to Competitive Fitness Loss of A/Shanghai/1/2013 (H7N9) Influenza Virus in Ferrets

BACKGROUND: Neuraminidase (NA) inhibitors are the only licensed therapeutic option for human zoonotic H7N9 infections. An NA-R292K mutation that confers broad-spectrum resistance to NA inhibitors has been documented in H7N9 patients after treatment. METHODS: We evaluated the transmission potential o...

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Detalhes bibliográficos
Publicado no:J Infect Dis
Main Authors: Yen, Hui-Ling, Zhou, Jie, Choy, Ka-Tim, Sia, Sin Fun, Teng, Ooiean, Ng, Iris H., Fang, Vicky J., Hu, Yunwen, Wang, Wei, Cowling, Benjamin J., Nicholls, John M., Guan, Yi, Peiris, Joseph Sriyal Malik
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2014
Assuntos:
Major Articles and Brief Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4296180/
https://ncbi.nlm.nih.gov/pubmed/24951824
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jiu353
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