Cell rigidity and shape override CD47’s “self”-signaling in phagocytosis by hyperactivating myosin-II

A macrophage engulfs another cell or foreign particle in an adhesive process that often activates myosin-II, unless the macrophage also engages “marker of self” CD47 that inhibits myosin. For many cell types, adhesion-induced activation of myosin-II is maximized by adhesion to a rigid rather than a...

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Bibliografiske detaljer
Udgivet i:Blood
Main Authors: Sosale, Nisha G., Rouhiparkouhi, Tahereh, Bradshaw, Andrew M., Dimova, Rumiana, Lipowsky, Reinhard, Discher, Dennis E.
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Hematology 2015
Fag:
Red Cells, Iron, and Erythropoiesis
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4296014/
https://ncbi.nlm.nih.gov/pubmed/25411427
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-06-585299
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