Red cells from ferrochelatase-deficient erythropoietic protoporphyria patients are resistant to growth of malarial parasites

Many red cell polymorphisms are a result of selective pressure by the malarial parasite. Here, we add another red cell disease to the panoply of erythrocytic changes that give rise to resistance to malaria. Erythrocytes from individuals with erythropoietic protoporphyria (EPP) have low levels of the...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Smith, Clare M., Jerkovic, Ante, Puy, Hervé, Winship, Ingrid, Deybach, Jean-Charles, Gouya, Laurent, van Dooren, Giel, Goodman, Christopher Dean, Sturm, Angelika, Manceau, Hana, McFadden, Geoffrey Ian, David, Peter, Mercereau-Puijalon, Odile, Burgio, Gaétan, McMorran, Brendan J., Foote, Simon J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2015
Assuntos:
Red Cells, Iron, and Erythropoiesis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4296013/
https://ncbi.nlm.nih.gov/pubmed/25414439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-04-567149
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