Red cells from ferrochelatase-deficient erythropoietic protoporphyria patients are resistant to growth of malarial parasites

Many red cell polymorphisms are a result of selective pressure by the malarial parasite. Here, we add another red cell disease to the panoply of erythrocytic changes that give rise to resistance to malaria. Erythrocytes from individuals with erythropoietic protoporphyria (EPP) have low levels of the...

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Veröffentlicht in:Blood
Hauptverfasser: Smith, Clare M., Jerkovic, Ante, Puy, Hervé, Winship, Ingrid, Deybach, Jean-Charles, Gouya, Laurent, van Dooren, Giel, Goodman, Christopher Dean, Sturm, Angelika, Manceau, Hana, McFadden, Geoffrey Ian, David, Peter, Mercereau-Puijalon, Odile, Burgio, Gaétan, McMorran, Brendan J., Foote, Simon J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Hematology 2015
Schlagworte:
Red Cells, Iron, and Erythropoiesis
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4296013/
https://ncbi.nlm.nih.gov/pubmed/25414439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-04-567149
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