Bi-directional modulation of incubation of cocaine craving by silent synapse-based remodeling of prefrontal cortex to accumbens projections

Glutamatergic projections from the medial prefrontal cortex (mPFC) to nucleus accumbens (NAc) contribute to cocaine relapse. Here we show that silent synapse-based remodeling of the two major mPFC-to-NAc projections differentially regulated the progressive increase in cue-induced cocaine seeking aft...

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Udgivet i:Neuron
Main Authors: Ma, Yao-Ying, Lee, Brian R., Wang, Xiusong, Guo, Changyong, Liu, Lei, Cui, Ranji, Lan, Yan, Balcita-Pedicino, Judith J., Wolf, Marina E., Sesack, Susan R., Shaham, Yavin, Schlüter, Oliver M., Huang, Yanhua H., Dong, Yan
Format: Artigo
Sprog:Inglês
Udgivet: 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4295617/
https://ncbi.nlm.nih.gov/pubmed/25199705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2014.08.023
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