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Development of a High Affinity, Non-covalent Biologic to Add Functionality to Fabs

Functionalization of monoclonal antibodies (mAbs) requires chemical derivatization and/or genetic manipulation. Inherent in these methods are challenges with protein heterogeneity, stability and solubility. Such perturbations could potentially be avoided by using a high affinity, non-covalent interm...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Sci Rep
Prif Awduron: Avery, Kendra N., Zer, Cindy, Bzymek, Krzysztof P., Williams, John C.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group 2015
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4295097/
https://ncbi.nlm.nih.gov/pubmed/25588710
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep07817
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