Dysregulation of lysosomal morphology by pathogenic LRRK2 is corrected by TPC2 inhibition

Two-pore channels (TPCs) are endolysosomal ion channels implicated in Ca(2+) signalling from acidic organelles. The relevance of these ubiquitous proteins for human disease, however, is unclear. Here, we report that lysosomes are enlarged and aggregated in fibroblasts from Parkinson disease patients...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:J Cell Sci
Main Authors: Hockey, Leanne N., Kilpatrick, Bethan S., Eden, Emily R., Lin-Moshier, Yaping, Brailoiu, G. Cristina, Brailoiu, Eugen, Futter, Clare E., Schapira, Anthony H., Marchant, Jonathan S., Patel, Sandip
Formato: Artigo
Idioma:Inglês
Publicado em: The Company of Biologists 2015
Assuntos:
Short Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4294771/
https://ncbi.nlm.nih.gov/pubmed/25416817
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.164152
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados