Dysregulation of lysosomal morphology by pathogenic LRRK2 is corrected by TPC2 inhibition

Two-pore channels (TPCs) are endolysosomal ion channels implicated in Ca(2+) signalling from acidic organelles. The relevance of these ubiquitous proteins for human disease, however, is unclear. Here, we report that lysosomes are enlarged and aggregated in fibroblasts from Parkinson disease patients...

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Библиографические подробности
Опубликовано в: :J Cell Sci
Главные авторы: Hockey, Leanne N., Kilpatrick, Bethan S., Eden, Emily R., Lin-Moshier, Yaping, Brailoiu, G. Cristina, Brailoiu, Eugen, Futter, Clare E., Schapira, Anthony H., Marchant, Jonathan S., Patel, Sandip
Формат: Artigo
Язык:Inglês
Опубликовано: The Company of Biologists 2015
Предметы:
Short Report
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4294771/
https://ncbi.nlm.nih.gov/pubmed/25416817
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.164152
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