Increased BDNF protein expression after ischemic or PKC epsilon preconditioning promotes electrophysiologic changes that lead to neuroprotection

Ischemic preconditioning (IPC) via protein kinase C epsilon (PKCɛ) activation induces neuroprotection against lethal ischemia. Brain-derived neurotrophic factor (BDNF) is a pro-survival signaling molecule that modulates synaptic plasticity and neurogenesis. Interestingly, BDNF mRNA expression increa...

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Dettagli Bibliografici
Pubblicato in:J Cereb Blood Flow Metab
Autori principali: Neumann, Jake T, Thompson, John W, Raval, Ami P, Cohan, Charles H, Koronowski, Kevin B, Perez-Pinzon, Miguel A
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2015
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4294405/
https://ncbi.nlm.nih.gov/pubmed/25370861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jcbfm.2014.185
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