Pleiotropic Effects of Cell Wall Amidase LytA on Streptococcus pneumoniae Sensitivity to the Host Immune Response

The complement system is a key component of the host immune response for the recognition and clearance of Streptococcus pneumoniae. In this study, we demonstrate that the amidase LytA, the main pneumococcal autolysin, inhibits complement-mediated immunity independently of effects on pneumolysin by a...

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Veröffentlicht in:Infect Immun
Hauptverfasser: Ramos-Sevillano, Elisa, Urzainqui, Ana, Campuzano, Susana, Moscoso, Miriam, González-Camacho, Fernando, Domenech, Mirian, Rodríguez de Córdoba, Santiago, Sánchez-Madrid, Francisco, Brown, Jeremy S., García, Ernesto, Yuste, Jose
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2015
Schlagworte:
Molecular Pathogenesis
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4294232/
https://ncbi.nlm.nih.gov/pubmed/25404032
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.02811-14
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