Metabolic characteristics of 13-cis-retinoic acid (isotretinoin) and anti-tumour activity of the 13-cis-retinoic acid metabolite 4-oxo-13-cis-retinoic acid in neuroblastoma

BACKGROUND AND PURPOSE: Isotretinoin (13-cis-retinoic acid; 13-cRA) is a differentiation inducer used to treat minimal residual disease after myeloablative therapy for high-risk neuroblastoma. However, more than 40% of children develop recurrent disease during or after 13-cRA treatment. The plasma c...

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Dettagli Bibliografici
Pubblicato in:Br J Pharmacol
Autori principali: Sonawane, Poonam, Cho, Hwang Eui, Tagde, Ashujit, Verlekar, Dattesh, Yu, Alice L, Reynolds, C Patrick, Kang, Min H
Natura: Artigo
Lingua:Inglês
Pubblicazione: BlackWell Publishing Ltd 2014
Soggetti:
Research Papers
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4294043/
https://ncbi.nlm.nih.gov/pubmed/25039756
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12846
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