UniPR129 is a competitive small molecule Eph-ephrin antagonist blocking in vitro angiogenesis at low micromolar concentrations

BACKGROUND AND PURPOSE: The Eph receptor tyrosine kinases and their ephrin ligands are key players in tumorigenesis and many reports have correlated changes in their expression with a poor clinical prognosis in many solid tumours. Agents targeting the Eph-ephrin system might emerge as new tools usef...

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Detalhes bibliográficos
Publicado no:Br J Pharmacol
Main Authors: Hassan-Mohamed, I, Giorgio, C, Incerti, M, Russo, S, Pala, D, Pasquale, E B, Zanotti, I, Vicini, P, Barocelli, E, Rivara, S, Mor, M, Lodola, A, Tognolini, M
Formato: Artigo
Idioma:Inglês
Publicado em: BlackWell Publishing Ltd 2014
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4294034/
https://ncbi.nlm.nih.gov/pubmed/24597515
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12669
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