Tolerance whole of genome doubling propagates chromosomal instability and accelerates cancer genome evolution

The contribution of whole genome doubling to chromosomal instability (CIN) and tumour evolution is unclear. We use long-term culture of isogenic tetraploid cells from a stable diploid colon cancer progenitor to investigate how a genome-doubling event affects genome stability over time. Rare cells th...

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Pubblicato in:Cancer Discov
Autori principali: Dewhurst, Sally M, McGranahan, Nicholas, Burrell, Rebecca A, Rowan, Andrew J, Grönroos, Eva, Endesfelder, David, Joshi, Tejal, Mouradov, Dmitri, Gibbs, Peter, Ward, Robyn L., Hawkins, Nicholas J., Szallasi, Zoltan, Sieber, Oliver M., Swanton, Charles
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4293454/
https://ncbi.nlm.nih.gov/pubmed/24436049
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-13-0285
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