Tolerance whole of genome doubling propagates chromosomal instability and accelerates cancer genome evolution

The contribution of whole genome doubling to chromosomal instability (CIN) and tumour evolution is unclear. We use long-term culture of isogenic tetraploid cells from a stable diploid colon cancer progenitor to investigate how a genome-doubling event affects genome stability over time. Rare cells th...

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Publicado en:Cancer Discov
Main Authors: Dewhurst, Sally M, McGranahan, Nicholas, Burrell, Rebecca A, Rowan, Andrew J, Grönroos, Eva, Endesfelder, David, Joshi, Tejal, Mouradov, Dmitri, Gibbs, Peter, Ward, Robyn L., Hawkins, Nicholas J., Szallasi, Zoltan, Sieber, Oliver M., Swanton, Charles
Formato: Artigo
Idioma:Inglês
Publicado: 2014
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4293454/
https://ncbi.nlm.nih.gov/pubmed/24436049
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-13-0285
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