ALS onset is influenced by the burden of rare variants in known ALS genes

OBJECTIVE: To define the genetic landscape of amyotrophic lateral sclerosis (ALS) and assess the contribution of possible oligogenic inheritance, we aimed to comprehensively sequence 17 known ALS genes in 391 ALS patients from the United States. METHODS: Targeted pooled-sample sequencing was used to...

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Detalhes bibliográficos
Publicado no:Ann Neurol
Main Authors: Cady, Janet, Allred, Peggy, Bali, Taha, Pestronk, Alan, Goate, Alison, Miller, Timothy M., Mitra, Rob, Ravits, John, Harms, Matthew B., Baloh, Robert H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4293318/
https://ncbi.nlm.nih.gov/pubmed/25382069
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ana.24306
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