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The vigorous immune microenvironment of microsatellite instable colon cancer is balanced by multiple counter-inhibitory checkpoints

We examined the immune microenvironment of primary colorectal cancer (CRC) using immunohistochemistry, laser capture microdissection/qRT-PCR, flow cytometry and functional analysis of tumor infiltrating lymphocytes. A subset of CRC displayed high infiltration with activated CD8(+) CTL as well as act...

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書目詳細資料
發表在:Cancer Discov
Main Authors: Llosa, Nicolas J., Cruise, Michael, Tam, Ada, Wick, Elizabeth C., Hechenbleikner, Elizabeth M., Taube, Janis M., Blosser, Lee, Fan, Hongni, Wang, Hao, Luber, Brandon, Zhang, Ming, Papadopoulos, Nickolas, Kinzler, Kenneth W., Vogelstein, Bert, Sears, Cynthia L., Anders, Robert A., Pardoll, Drew M., Housseau, Franck
格式: Artigo
語言:Inglês
出版: 2014
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4293246/
https://ncbi.nlm.nih.gov/pubmed/25358689
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-14-0863
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