The vigorous immune microenvironment of microsatellite instable colon cancer is balanced by multiple counter-inhibitory checkpoints

We examined the immune microenvironment of primary colorectal cancer (CRC) using immunohistochemistry, laser capture microdissection/qRT-PCR, flow cytometry and functional analysis of tumor infiltrating lymphocytes. A subset of CRC displayed high infiltration with activated CD8(+) CTL as well as act...

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Veröffentlicht in:Cancer Discov
Hauptverfasser: Llosa, Nicolas J., Cruise, Michael, Tam, Ada, Wick, Elizabeth C., Hechenbleikner, Elizabeth M., Taube, Janis M., Blosser, Lee, Fan, Hongni, Wang, Hao, Luber, Brandon, Zhang, Ming, Papadopoulos, Nickolas, Kinzler, Kenneth W., Vogelstein, Bert, Sears, Cynthia L., Anders, Robert A., Pardoll, Drew M., Housseau, Franck
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4293246/
https://ncbi.nlm.nih.gov/pubmed/25358689
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-14-0863
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