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Genetic variation in the UGT1A locus is associated with simvastatin efficacy in a clinical practice setting
AIM: Simvastatin is a lactone prodrug that exists in equilibrium with its active hydroxyacid through a process mediated by UGT1A enzymes. The UGT1A locus has been associated with simvastatin response and disposition in humans. Therefore, we fine-mapped the UGT1A locus to identify genetic variations...
Αποθηκεύτηκε σε:
| Τόπος έκδοσης: | Pharmacogenomics |
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| Κύριοι συγγραφείς: | , , , , , , , , , , |
| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
2014
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4292894/ https://ncbi.nlm.nih.gov/pubmed/25493567 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2217/pgs.14.128 |
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