Prevalence of Neutralizing Antibodies against Adeno-Associated Virus (AAV) Types 2, 5, and 6 in Cystic Fibrosis and Normal Populations: Implications for Gene Therapy using AAV Vectors

Adeno-associated virus (AAV) vectors are promising candidates for gene therapy directed to the lungs, in particular for treatment of cystic fibrosis (CF). In animal models of lung gene transfer, neutralizing antibodies in serum made in response to vector exposure have been associated with a partial...

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Vydáno v:Hum Gene Ther
Hlavní autoři: Halbert, Christine L., Miller, A. Dusty, McNamara, Sharon, Emerson, Julia, Gibson, Ronald L., Ramsey, Bonnie, Aitken, Moira L.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2006
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4292890/
https://ncbi.nlm.nih.gov/pubmed/16610931
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hum.2006.17.440
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