The kinase inhibitors dabrafenib and trametinib affect isolated immune cell populations

Metastatic melanoma is frequently fatal. Optimal treatment regimens require both rapid and durable disease control, likely best achieved by combining targeted agents with immunotherapeutics. In order to accomplish this, a detailed understanding of the immune consequences of the kinase inhibitors use...

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Veröffentlicht in:Oncoimmunology
Hauptverfasser: Vella, Laura J, Andrews, Miles C, Pasam, Anupama, Woods, Katherine, Behren, Andreas, Cebon, Jonathan S
Format: Artigo
Sprache:Inglês
Veröffentlicht: Taylor & Francis 2014
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4292757/
https://ncbi.nlm.nih.gov/pubmed/25610732
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/21624011.2014.946367
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