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Chimeric antigen receptor engineered T cells can eliminate brain tumors and initiate long-term protection against recurrence

CAR therapy has shown promise in treating cancer, but at the cost of unexpected toxicity against normal tissues, not predicted by preclinical testing. We are working to generate more physiologically relevant models for preclinical CAR toxicity testing, and in doing so, have discovered that CAR thera...

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Detalhes bibliográficos
Publicado no:Oncoimmunology
Main Authors: Johnson, Laura A, Sanchez-Perez, Luis, Suryadevara, Carter M, Sampson, John H
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2014
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4292711/
https://ncbi.nlm.nih.gov/pubmed/25610729
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/21624011.2014.944059
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