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Synthesis and Biological Evaluation of Pyrazolo[1,5-a]pyrimidine Compounds as Potent and Selective Pim-1 Inhibitors
[Image: see text] Pim-1 has emerged as an attractive target for developing therapeutic agents for treating disorders involving abnormal cell growth, especially cancers. Herein we present lead optimization, chemical synthesis and biological evaluation of pyrazolo[1,5-a]pyrimidine compounds as potent...
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| הוצא לאור ב: | ACS Med Chem Lett |
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| Main Authors: | , , , , , , , , , , |
| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
American Chemical
Society
2014
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| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4291737/ https://ncbi.nlm.nih.gov/pubmed/25589932 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml500300c |
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