Synthesis and Biological Evaluation of Pyrazolo[1,5-a]pyrimidine Compounds as Potent and Selective Pim-1 Inhibitors

[Image: see text] Pim-1 has emerged as an attractive target for developing therapeutic agents for treating disorders involving abnormal cell growth, especially cancers. Herein we present lead optimization, chemical synthesis and biological evaluation of pyrazolo[1,5-a]pyrimidine compounds as potent...

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Detalhes bibliográficos
Publicado no:ACS Med Chem Lett
Main Authors: Xu, Yong, Brenning, Benjamin G., Kultgen, Steven G., Foulks, Jason M., Clifford, Adrianne, Lai, Shuping, Chan, Ashley, Merx, Shannon, McCullar, Michael V., Kanner, Steven B., Ho, Koc-Kan
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2014
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4291737/
https://ncbi.nlm.nih.gov/pubmed/25589932
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml500300c
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