Synthesis and Biological Evaluation of Pyrazolo[1,5-a]pyrimidine Compounds as Potent and Selective Pim-1 Inhibitors

[Image: see text] Pim-1 has emerged as an attractive target for developing therapeutic agents for treating disorders involving abnormal cell growth, especially cancers. Herein we present lead optimization, chemical synthesis and biological evaluation of pyrazolo[1,5-a]pyrimidine compounds as potent...

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Publicado en:ACS Med Chem Lett
Autores principales: Xu, Yong, Brenning, Benjamin G., Kultgen, Steven G., Foulks, Jason M., Clifford, Adrianne, Lai, Shuping, Chan, Ashley, Merx, Shannon, McCullar, Michael V., Kanner, Steven B., Ho, Koc-Kan
Formato: Artigo
Lenguaje:Inglês
Publicado: American Chemical Society 2014
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4291737/
https://ncbi.nlm.nih.gov/pubmed/25589932
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml500300c
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