Synthesis and Biological Evaluation of Pyrazolo[1,5-a]pyrimidine Compounds as Potent and Selective Pim-1 Inhibitors

[Image: see text] Pim-1 has emerged as an attractive target for developing therapeutic agents for treating disorders involving abnormal cell growth, especially cancers. Herein we present lead optimization, chemical synthesis and biological evaluation of pyrazolo[1,5-a]pyrimidine compounds as potent...

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Veröffentlicht in:ACS Med Chem Lett
Hauptverfasser: Xu, Yong, Brenning, Benjamin G., Kultgen, Steven G., Foulks, Jason M., Clifford, Adrianne, Lai, Shuping, Chan, Ashley, Merx, Shannon, McCullar, Michael V., Kanner, Steven B., Ho, Koc-Kan
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Chemical Society 2014
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4291737/
https://ncbi.nlm.nih.gov/pubmed/25589932
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml500300c
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