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Synthesis and Biological Evaluation of Pyrazolo[1,5-a]pyrimidine Compounds as Potent and Selective Pim-1 Inhibitors
[Image: see text] Pim-1 has emerged as an attractive target for developing therapeutic agents for treating disorders involving abnormal cell growth, especially cancers. Herein we present lead optimization, chemical synthesis and biological evaluation of pyrazolo[1,5-a]pyrimidine compounds as potent...
Wedi'i Gadw mewn:
Cyhoeddwyd yn: | ACS Med Chem Lett |
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Prif Awduron: | , , , , , , , , , , |
Fformat: | Artigo |
Iaith: | Inglês |
Cyhoeddwyd: |
American Chemical
Society
2014
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Mynediad Ar-lein: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4291737/ https://ncbi.nlm.nih.gov/pubmed/25589932 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml500300c |
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