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Synthesis and Biological Evaluation of Pyrazolo[1,5-a]pyrimidine Compounds as Potent and Selective Pim-1 Inhibitors

[Image: see text] Pim-1 has emerged as an attractive target for developing therapeutic agents for treating disorders involving abnormal cell growth, especially cancers. Herein we present lead optimization, chemical synthesis and biological evaluation of pyrazolo[1,5-a]pyrimidine compounds as potent...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:ACS Med Chem Lett
Prif Awduron: Xu, Yong, Brenning, Benjamin G., Kultgen, Steven G., Foulks, Jason M., Clifford, Adrianne, Lai, Shuping, Chan, Ashley, Merx, Shannon, McCullar, Michael V., Kanner, Steven B., Ho, Koc-Kan
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Chemical Society 2014
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4291737/
https://ncbi.nlm.nih.gov/pubmed/25589932
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml500300c
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