Continuous versus Short-Term Infusion of Cefuroxime: Assessment of Concept Based on Plasma, Subcutaneous Tissue, and Bone Pharmacokinetics in an Animal Model

The relatively short half-lives of most β-lactams suggest that continuous infusion of these time-dependent antimicrobials may be favorable compared to short-term infusion. Nevertheless, only limited solid-tissue pharmacokinetic data are available to support this theory. In this study, we randomly as...

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Vydáno v:Antimicrob Agents Chemother
Hlavní autoři: Tøttrup, Mikkel, Bibby, Bo M., Hardlei, Tore F., Bue, Mats, Kerrn-Jespersen, Sigrid, Fuursted, Kurt, Søballe, Kjeld, Birke-Sørensen, Hanne
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2014
Témata:
Pharmacology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4291408/
https://ncbi.nlm.nih.gov/pubmed/25313214
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.03857-14
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