Nonclinical and Pharmacokinetic Assessments To Evaluate the Potential of Tedizolid and Linezolid To Affect Mitochondrial Function

Prolonged treatment with the oxazolidinone linezolid is associated with myelosuppression, lactic acidosis, and neuropathies, toxicities likely caused by impairment of mitochondrial protein synthesis (MPS). To evaluate the potential of the novel oxazolidinone tedizolid to cause similar side effects,...

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Udgivet i:Antimicrob Agents Chemother
Main Authors: Flanagan, Shawn, McKee, Edward E., Das, Debaditya, Tulkens, Paul M., Hosako, Hiromi, Fiedler-Kelly, Jill, Passarell, Julie, Radovsky, Ann, Prokocimer, Philippe
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2014
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Mechanisms of Action: Physiological Effects
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4291347/
https://ncbi.nlm.nih.gov/pubmed/25331703
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.03684-14
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