Risk of childhood asthma is associated with CpG-site polymorphisms, regional DNA methylation and mRNA levels at the GSDMB/ORMDL3 locus

Single-nucleotide polymorphisms (SNPs) in GSDMB (Gasdermin B) and ORMDL3 (ORMDL sphingolipid biosynthesis regulator 3) are strongly associated with childhood asthma, but the molecular alterations contributing to disease remain unknown. We investigated the effects of asthma-associated SNPs on DNA met...

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Detalhes bibliográficos
Publicado no:Hum Mol Genet
Principais autores: Acevedo, Nathalie, Reinius, Lovisa E., Greco, Dario, Gref, Anna, Orsmark-Pietras, Christina, Persson, Helena, Pershagen, Göran, Hedlin, Gunilla, Melén, Erik, Scheynius, Annika, Kere, Juha, Söderhäll, Cilla
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2015
Assuntos:
Association Studies Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4291244/
https://ncbi.nlm.nih.gov/pubmed/25256354
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddu479
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