Fragment based group QSAR and molecular dynamics mechanistic studies on arylthioindole derivatives targeting the α-β interfacial site of human tubulin

BACKGROUND: A number of microtubule disassembly blocking agents and inhibitors of tubulin polymerization have been elements of great interest in anti-cancer therapy, some of them even entering into the clinical trials. One such class of tubulin assembly inhibitors is of arylthioindole derivatives wh...

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Bibliographische Detailangaben
Veröffentlicht in:BMC Genomics
Hauptverfasser: Tyagi, Chetna, Gupta, Ankita, Goyal, Sukriti, Dhanjal, Jaspreet Kaur, Grover, Abhinav
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2014
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4290613/
https://ncbi.nlm.nih.gov/pubmed/25521775
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2164-15-S9-S3
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