Cholesterol-conjugated let-7a mimics: antitumor efficacy on hepatocellular carcinoma in vitro and in a preclinical orthotopic xenograft model of systemic therapy

BACKGROUND: A major challenge to the clinical utility of let-7 for hepatocellular carcinoma (HCC) therapy is the lack of an effective carrier to target tumours. We confirmed the high transfection efficiency of cholesterol-conjugated let-7a miRNA mimics (Chol-let-7a) in human HCC cells, as well as th...

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Bibliografiske detaljer
Udgivet i:BMC Cancer
Main Authors: Liu, Yang Ming, Xia, Yu, Dai, Wei, Han, Hua Ye, Dong, Yu Xue, Cai, Jiong, Zeng, Xuan, Luo, Feng Yu, Yang, Tao, Li, Yuan Zhi, Chen, Jie, Guan, Jian
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2014
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4289300/
https://ncbi.nlm.nih.gov/pubmed/25429777
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-14-889
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