A Bivalent Typhoid Live Vector Vaccine Expressing both Chromosome- and Plasmid-Encoded Yersinia pestis Antigens Fully Protects against Murine Lethal Pulmonary Plague Infection

Live attenuated bacteria hold great promise as multivalent mucosal vaccines against a variety of pathogens. A major challenge of this approach has been the successful delivery of sufficient amounts of vaccine antigens to adequately prime the immune system without overattenuating the live vaccine. He...

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Publicat a:Infect Immun
Autors principals: Galen, James E., Wang, Jin Yuan, Carrasco, Jose A., Lloyd, Scott A., Mellado-Sanchez, Gabriela, Diaz-McNair, Jovita, Franco, Olga, Buskirk, Amanda D., Nataro, James P., Pasetti, Marcela F.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2014
Matèries:
Microbial Immunity and Vaccines
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4288866/
https://ncbi.nlm.nih.gov/pubmed/25332120
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.02443-14
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