Impact of Detergent on Biophysical Properties and Immune Response of the IpaDB Fusion Protein, a Candidate Subunit Vaccine against Shigella Species

Shigella spp. are causative agents of bacillary dysentery, a human illness with high global morbidity levels, particularly among elderly and infant populations. Shigella infects via the fecal-oral route, and its virulence is dependent upon a type III secretion system (T3SS). Two components of the ex...

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Bibliographic Details
Published in:Infect Immun
Main Authors: Chen, Xiaotong, Choudhari, Shyamal P., Martinez-Becerra, Francisco J., Kim, Jae Hyun, Dickenson, Nicholas E., Toth, Ronald T., Joshi, Sangeeta B., Greenwood, Jamie C., Clements, John D., Picking, William D., Middaugh, C. Russell, Picking, Wendy L.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2014
Subjects:
Microbial Immunity and Vaccines
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4288857/
https://ncbi.nlm.nih.gov/pubmed/25368115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.02457-14
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