Roles of PCNA ubiquitination and TLS polymerases κ and η in the bypass of methyl methanesulfonate-induced DNA damage

Translesion synthesis (TLS) provides a highly conserved mechanism that enables DNA synthesis on a damaged template. TLS is performed by specialized DNA polymerases of which polymerase (Pol) κ is important for the cellular response to DNA damage induced by benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide...

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Udgivet i:Nucleic Acids Res
Main Authors: Wit, Niek, Buoninfante, Olimpia Alessandra, van den Berk, Paul C.M., Jansen, Jacob G., Hogenbirk, Marc A., de Wind, Niels, Jacobs, Heinz
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2015
Fag:
Genome Integrity, Repair and Replication
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4288191/
https://ncbi.nlm.nih.gov/pubmed/25505145
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku1301
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