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Overexpression of miR-146a in basal-like breast cancer cells confers enhanced tumorigenic potential in association with altered p53 status

The tumor suppressor p53 is the most frequently mutated gene in human cancers, mutated in 25–30% of breast cancers. However, mutation rates differ according to breast cancer subtype, being more prevalent in aggressive estrogen receptor-negative tumors and basal-like and HER2-amplified subtypes. This...

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Bibliografiske detaljer
Udgivet i:Carcinogenesis
Main Authors: Sandhu, Rupninder, Rein, Jessica, D’Arcy, Monica, Herschkowitz, Jason I., Hoadley, Katherine A., Troester, Melissa A.
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2014
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Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4288116/
https://ncbi.nlm.nih.gov/pubmed/25123132
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgu175
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