Combined deletion of Pten and p53 in mammary epithelium accelerates triple-negative breast cancer with dependency on eEF2K

The tumor suppressors Pten and p53 are frequently lost in breast cancer, yet the consequences of their combined inactivation are poorly understood. Here, we show that mammary-specific deletion of Pten via WAP-Cre, which targets alveolar progenitors, induced tumors with shortened latency compared to...

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Библиографические подробности
Опубликовано в: :EMBO Mol Med
Главные авторы: Liu, Jeff C, Voisin, Veronique, Wang, Sharon, Wang, Dong-Yu, Jones, Robert A, Datti, Alessandro, Uehling, David, Al-awar, Rima, Egan, Sean E, Bader, Gary D, Tsao, Ming, Mak, Tak W, Zacksenhaus, Eldad
Формат: Artigo
Язык:Inglês
Опубликовано: BlackWell Publishing Ltd 2014
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Research Articles
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4287974/
https://ncbi.nlm.nih.gov/pubmed/25330770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/emmm.201404402
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