Tipping the MYC–MIZ1 balance: targeting the HUWE1 ubiquitin ligase selectively blocks MYC-activated genes

MYC family oncoproteins (MYC, N-MYC and L-MYC) function as basic helix-loop-helix-leucine zipper (bHLH-Zip) transcription factors that are activated (i.e., overexpressed) in well over half of all human malignancies (Boxer & Dang, 2001; Beroukhim et al, 2010). In this issue of EMBO Molecular Medi...

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Bibliographic Details
Published in:EMBO Mol Med
Main Authors: Schaub, Franz X, Cleveland, John L
Format: Artigo
Language:Inglês
Published: BlackWell Publishing Ltd 2014
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4287968/
https://ncbi.nlm.nih.gov/pubmed/25368331
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/emmm.201404735
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