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Adenosine analogs with covalently attached lipids have enhanced potency at A(1)-adenosine receptors

Chemically functionalized congeners of N(6)-phenyladenosine and I ,3-dipropyl-8-phenylxanthine have been covalently coupled to fatty acids, diglyceridcs, and a phospholipid. The lipid-drug conjugates inhibit R-[(3)H]-phenylisopropyladenosinc binding to A(1)-adcnosine receptors in rat cerebral cortex...

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Foilsithe in:FEBS Lett
Main Authors: Jacobson, Kenneth A., Zimmet, Jeffrey, Schulick, Richard, Barone, Suzanne, Daly, John W., Kirk, Kenneth L.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 1987
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Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4287258/
https://ncbi.nlm.nih.gov/pubmed/3691809
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