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Itk Signals Promote Neuroinflammation by Regulating CD4(+) T-Cell Activation and Trafficking
Here we demonstrate that interleukin-2-inducible T-cell kinase (Itk) signaling in cluster of differentiation 4-positive (CD4(+)) T cells promotes experimental autoimmune encephalomyelitis (EAE), the animal model of multiple sclerosis (MS). We show that Itk(−/−) mice exhibit reduced disease severity,...
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| Pubblicato in: | J Neurosci |
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| Autori principali: | , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Society for Neuroscience
2015
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4287144/ https://ncbi.nlm.nih.gov/pubmed/25568116 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1957-14.2015 |
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