Telomerase inhibition abolishes the tumorigenicity of pediatric ependymoma tumor-initiating cells

Pediatric ependymomas are highly recurrent tumors resistant to conventional chemotherapy. Telomerase, a ribonucleoprotein critical in permitting limitless replication, has been found to be critically important for the maintenance of tumor-initiating cells (TICs). These TICs are chemoresistant, repop...

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Bibliographic Details
Published in:Acta Neuropathol
Main Authors: Barszczyk, Mark, Buczkowicz, Pawel, Castelo-Branco, Pedro, Mack, Stephen C., Ramaswamy, Vijay, Mangerel, Joshua, Agnihotri, Sameer, Remke, Marc, Golbourn, Brian, Pajovic, Sanja, Elizabeth, Cynthia, Yu, Man, Luu, Betty, Morrison, Andrew, Adamski, Jennifer, Nethery-Brokx, Kathleen, Li, Xiao-Nan, Van Meter, Timothy, Dirks, Peter B., Rutka, James T., Taylor, Michael D., Tabori, Uri, Hawkins, Cynthia
Format: Artigo
Language:Inglês
Published: Springer Berlin Heidelberg 2014
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Original Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4286630/
https://ncbi.nlm.nih.gov/pubmed/25120190
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-014-1327-6
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