BI-21 BRAF MUTATION AND CDKN2A DELETIONS DEFINE A CLINICALLY DISTINCT SUBGROUP OF CHILDHOOD SECONDARY HIGH GRADE GLIOMA

PURPOSE: Pediatric secondary high grade glioma (sHGG), which result from malignant transformation of low grade glioma (PLGG), are a poorly understood group of tumors with devastating outcomes. PATIENTS AND METHODS: We performed a population-based study combined with long-term follow-up of PLGG that...

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Detalhes bibliográficos
Main Authors: Mistry, Matthew, Zhukova, Nataliya, Merico, Daniele, Rakopoulos, Patricia, Krishnatry, Rahul, Shago, Mary, Stavropoulos, Jim, Ray, Peter, Mangerel, Joshua, Remke, Marc, Buczkowicz, Pawel, Ramaswamy, Vijay, Rutka, James, Dirks, Peter, Taylor, Michael, Bouffet, Eric, Malkin, David, Huang, Annie, Hawkins, Cynthia, Tabori, Uri
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2014
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4217889/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nou239.21
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