Detection of a Recurrent DNAJB1-PRKACA Chimeric Transcript in Fibrolamellar Hepatocellular Carcinoma

Fibrolamellar hepatocellular carcinoma (FL-HCC) is a rare liver tumor affecting adolescents and young adults who have no history of primary liver disease or cirrhosis. We performed RNA sequencing on FL-HCC tumors and identified a chimeric transcript that was expressed in all tumor samples but not in...

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Veröffentlicht in:Science
Hauptverfasser: Honeyman, Joshua N., Simon, Elana P., Robine, Nicolas, Chiaroni-Clarke, Rachel, Darcy, David G., Lim, Irene Isabel P., Gleason, Caroline E., Murphy, Jennifer, Rosenberg, Brad R., Teegan, Lydia, Takacs, Constantin N., Botero, Sergio, Belote, Rachel, Germer, Soren, Emde, Anne-Katrin, Vacic, Vladimir, Bhanot, Umesh, LaQuaglia, Michael P., Simon, Sanford M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4286414/
https://ncbi.nlm.nih.gov/pubmed/24578576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1249484
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