Carnitine Palmitoyltransferase 1b Deficient Mice Develop Severe Insulin Resistance After Prolonged High Fat Diet Feeding

BACKGROUND: Carnitine palmitoyltransferase 1 (CPT1) is the rate-limiting enzyme governing the entry of long-chain acyl-CoAs into mitochondria. Treatments with CPT1 inhibitors protect against insulin resistance in short-term preclinical animal studies. We recently reported that mice with muscle isofo...

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Bibliographic Details
Published in:J Diabetes Metab
Main Authors: Kim, Teayoun, Moore, John F, Sharer, Jon D, Yang, Kevin, Wood, Philip A, Yang, Qinglin
Format: Artigo
Language:Inglês
Published: 2014
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4286342/
https://ncbi.nlm.nih.gov/pubmed/25580367
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4172/2155-6156.1000401
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