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3,5-Diamino-1,2,4-triazoles as a novel scaffold for potent, reversible LSD1 (KDM1A) inhibitors

The chromatin remodeling amine oxidase lysine-specific demethylase 1 (LSD1) has become an attractive target for the design of specific inhibitors with therapeutic potential. We, and others, have described LSD1 inhibitors that have potential as antitumor agents. Many of the currently known LSD1 inhib...

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Bibliografski detalji
Izdano u:Medchemcomm
Glavni autori: Kutz, Craig J., Holshouser, Steven L., Marrow, Ethan A., Woster, Patrick M.
Format: Artigo
Jezik:Inglês
Izdano: 2014
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4286191/
https://ncbi.nlm.nih.gov/pubmed/25580204
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/C4MD00283K
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